In Sporting News' first picks and predictions against the spread for the 2026 NFL regular season, the Seahawks and Rams get off to great starts as co-favorites in the NFC West, while the Giants and Eagles win in their opening NFC East matchups.

Our NFL staff makes picks for every Week 1 NFL game. From Patriots-Seahawks to Broncos-Chiefs, here's a look at the biggest games.

The 49ers asked the NFL for a Monday night Week 2 game after opening the season in Australia. Kyle Shanahan revealed the league denied the request.

San Francisco 49ers tight end George Kittle is eight months removed from a torn Achilles he suffered during the 2025 season.

The NFL match between the Los Angeles Rams and San Francisco 49ers is an entertainment extravaganza. Not only will there be performances on the MCG, but also in the precinct surrounding the famous venue.

Tim Kawakami floated the idea of SF reuniting with DT DeForest Buckner after Alfred Collins' season-ending injury.

NFL Week 1 announcers, channels, streaming information, times for every game on the NFL Week 1 schedule this week. Who is announcing each NFL game?

Gonzalez is now one of just two cornerbacks in NFL history to reach a deal worth more than $130 million. Seattle Seahawks star Devon Witherspoon signed a four-year, $132 million extension last month, which briefly made him the highest-paid player at the position.