Collagen is one of the leading components in extracellular matrix (ECM), providing durability, structural integrity, and functionality for many tissues. Regulation of collagen fibrillogenesis and ...
Proteoglycans—molecules consisting of a core protein with multiple sugar chains—are so complex that researchers usually study the protein and sugar components separately, which makes it difficult to ...
“RPTPσ is a transmembrane enzyme known to bind proteoglycans through its extracellular domain, and to regulate axonal elongation in response to cell surface and extracellular proteoglycans in neurons, ...
LA JOLLA, CA—Scientists at Scripps Research have developed a set of methods for the closer study of one of the least-accessible, least-understood players in biology: protein-sugar conjugates called ...
Historically, proteoglycans have been viewed as a rather obscure family of complex glycoproteins that perform mainly passive structural roles in the extracellular matrix. Indeed, as pointed out in the ...
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