Cells of a multicellular organism are functionally heterogeneous owing to the differential expression of genes. Historically, differential gene expression had been thought to involve the genetic ...

The capacity of an organism to regenerate depends on cell dedifferentiation followed by proliferation. Mammals, in general, have limited regenerative capacity. Now, a team of researchers at the Salk ...

Age-related memory decline and neurodegenerative diseases like Alzheimer's are often thought of as irreversible. But the brain is not static; neurons continually adjust the strength of their ...

This Review summarizes the progress to date on efforts to understand the molecular mechanisms underlying transcription factor-induced reprogramming of somatic cells to a pluripotent state (known as ...

A novel study using a mouse model has found that the absence of the angiopoietin-like 4 (ANGPTL4) protein during development ...

It is well known that adding a mixture of four reprogramming molecules (Oct4, Sox2, Klf4 and c-Myc) also known as “Yamanaka factors” to cells can reset epigenetic marks to their original patterns.

Prostate cancer (PCa) is one of the most common malignant tumors among men worldwide. Following androgen deprivation therapy (ADT), the disease often progresses to castration-resistant prostate cancer ...

Stimulating a key metabolic pathway in T cells can make them work more effectively against tumors when combined with immune checkpoint inhibitor therapy, according to a preclinical study. The findings ...

EPFL researchers have uncovered how transcription factor dosage reshapes cell identity, showing that even small differences in dose can steer cells toward completely different fates. Their findings ...

Abnormalities in the TME contribute to immunosuppression and dictate the outcome of various immunotherapeutic approaches. Reprogramming specific facets of the immune compartment, such as ...