The Cowboys have a new-look defense with new defensive coordinator Christian Parker and first-round pick Caleb Downs. The John Harbaugh era begins in New York. Dak Prescott is 14-3 S/U against the Giants – and Dallas has won nine of the last 10 meetings.

Welcome to Week 1 of another new NFL survivor pool season! The timing of this year’s kickoff couldn’t be better: Coming off a long holiday weekend — in the United States, anyway — we only have to wait two days for real football.

SportsLine's advanced model has locked in its Week 1 NFL predictions today from 10,000 simulations

In Sporting News' first picks and predictions against the spread for the 2026 NFL regular season, the Seahawks and Rams get off to great starts as co-favorites in the NFC West, while the Giants and Eagles win in their opening NFC East matchups.